Stable isotope-resolved metabolomics based on mass spectrometry: Methods and their applications

D Yu, L Zhou, X Liu, G Xu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
The introduction of stable isotope labeling (SIL) technology into metabolomics can provide
insight into the" dynamic" metabolic regulation in organisms and has recently become a …

Mitochondrial lipid signaling and adaptive thermogenesis

H Von Bank, M Hurtado-Thiele, N Oshimura, J Simcox - Metabolites, 2021 - mdpi.com
Thermogenesis is an energy demanding process by which endotherms produce heat to
maintain their body temperature in response to cold exposure. Mitochondria in the brown …

Graphene quantum dots disturbed the energy homeostasis by influencing lipid metabolism of macrophages

Y Shao, X Wang, L Wang, Y Huang, Q Wei, W Sun… - Toxicology, 2023 - Elsevier
To investigate the potential factors of graphene quantum dots (GQDs), the assessment
impact on the innate immune system is one of the most important. As the innate immune cell …

Model validation and selection in metabolic flux analysis and flux balance analysis

JAM Kaste, Y Shachar‐Hill - Biotechnology Progress, 2024 - Wiley Online Library
Abstract 13C‐Metabolic Flux Analysis (13C‐MFA) and Flux Balance Analysis (FBA) are
widely used to investigate the operation of biochemical networks in both biological and …

[HTML][HTML] 代谢组学在胶质母细胞瘤相关研究中的应用

龚俊杰, 刘秀秀, 王平, 张璐璐 - 南京医科大学学报(自然科学版), 2021 - jnmu.njmu.edu.cn
摘要代谢组学是肿瘤研究领域颇受关注的研究方法. 其理论基础是肿瘤存在有别于正常组织的
代谢特征, 并且这种代谢改变与生物表型存在紧密的关联. 代谢组学通过高通量的检测手段 …

Stable isotope-based metabolic flux analysis: A robust tool for revealing toxicity pathways of emerging contaminants

R Zhang, B Chen, H Zhang, L Tu, T Luan - TrAC Trends in Analytical …, 2023 - Elsevier
Metabolic flux analysis (MFA) is an attractive tool to determine metabolic pathway activities
that are regarded as the fifth layer of system biology. The information regarding metabolic …

Improved 13C metabolic flux analysis in Escherichia coli metabolism: application of a high-resolution MS (GC–EI–QTOF) for comprehensive assessment of MS/MS …

C Richter, E Grafahrend-Belau, J Ziegler… - Journal of Industrial …, 2023 - academic.oup.com
Gas chromatography–tandem mass spectrometry with electron ionization (GC–EI–MS/MS)
provides rich information on stable-isotope labeling for 13C-metabolic flux analysis (13C …

Leveraging high-resolution mass spectrometry detection of stable isotopes for metabolomics

JD Gomez - 2024 - search.proquest.com
In recent decades, the use of stable isotopes in metabolomics has fueled groundbreaking
discoveries in metabolism research, enabling the tracking of metabolically active …

[PDF][PDF] Insights from modeling metabolism and amoeboid cell motility in the immune

L Steijn - Cell, 2021 - scholarlypublications …
Multicellular organisms, including plants and animals, continuously struggle with infections
by bacteria, fungi and viruses. In animals, infections are cleared by the innate and acquired …

Leveraging high-resolution mass spectrometry detection of stable isotopes for metabolomics

JD Gomez Castro - 2024 - ir.vanderbilt.edu
In recent decades, the use of stable isotopes in metabolomics has fueled groundbreaking
discoveries in metabolism research, enabling the tracking of metabolically active …