It is now widely appreciated that the spatial organization of the genome is nonrandom, and
its complex 3D folding has important consequences for many genome processes. Recent …

The discovery and development of targeted protein degraders have become important areas
of research in the field of medicinal chemistry. Inducing degradation of a target protein …

Polycomb group (PcG) proteins repress master regulators of development and differentiation
through organization of chromatin structure. Mutation and dysregulation of PcG genes cause …

The Polycomb PRC1 plays essential roles in development and disease pathogenesis.
Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins …

Over-expression of fluorescently-labeled markers for extracellular vesicles is frequently used
to visualize vesicle up-take and transport. EVs that are labeled by over-expression show …

Within a cell, multiple copies of the same protein coexist in different pathways and behave
differently. Being able to individually analyze the constant actions of proteins in a cell is …

A full understanding of RNA silencing requires appropriate molecular biology tools to
explore the roles of Argonaute 2 (AGO2) and the RNA-induced silencing complex (RISC) …

Polycomb group (PcG) proteins are master regulators of development and differentiation.
Mutation and dysregulation of PcG genes cause developmental defects and cancer. PcG …