Physiological closed-loop controlled medical devices automatically adjust therapy delivered
to a patient to adjust a measured physiological variable. In critical care scenarios, these …

There are at least two approaches to the definition of consciousness. In the first case, certain
aspects of consciousness, called qualia, are considered inaccessible for research from a …

Purpose Anesthesiologists simultaneously manage several aspects of patient care during
general anesthesia. Automating administration of hypnotic agents could enable more …

Objective. Personalized automatic control of medically-induced coma, a critical multi-day
therapy in the intensive care unit, could greatly benefit clinical care and further provide a …

Objective. Design of closed-loop anesthetic delivery (CLAD) systems is an important topic,
particularly for medically induced coma, which needs to be maintained for long periods …

A continuous isoelectric electroencephalogram reflects an interruption of endogenously-
generated activity in cortical networks and systematically results in a complete dissolution of …

Objective To characterize the amount of EEG suppression achieved in refractory status
epilepticus (RSE) patients treated with pharmacologically-induced coma (PIC). Methods We …

Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication
regimen. Prior studies have used deterministic and value-based tabular learning to learn a …

Model-based drug administration: current status of target-co... : Current Opinion in
Anesthesiology Model-based drug administration: current status of target-controlled infusion and …

Objective. Closed-loop deep brain stimulation (DBS) is a promising therapy for Parkinson's
disease (PD) that works by adjusting DBS patterns in real time from the guidance of …