Intranasal COVID-19 vaccines: From bench to bed

A Alu, L Chen, H Lei, Y Wei, X Tian, X Wei - EBioMedicine, 2022 - thelancet.com
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies

D Shan, S Li, R Xu, G Nie, Y Xie, J Han… - Frontiers in aging …, 2022 - frontiersin.org
Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory
impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light …

Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

J Villadiego, J García-Arriaza, R Ramírez-Lorca… - Nature …, 2023 - nature.com
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective
efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18 …

Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine

L Douguet, I Fert, J Lopez, B Vesin… - EMBO Molecular …, 2023 - embopress.org
Human papillomavirus (HPV) infections are the cause of all cervical and numerous
oropharyngeal and anogenital cancers. The currently available HPV vaccines, which induce …

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa

B Vesin, J Lopez, A Noirat, P Authié, I Fert… - Molecular Therapy, 2022 - cell.com
As the coronavirus disease 2019 (COVID-19) pandemic continues and new severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern emerge, the adaptive …

Lentiviral vectors as a vaccine platform against infectious diseases

K Nemirov, M Bourgine, F Anna, Y Wei, P Charneau… - Pharmaceutics, 2023 - mdpi.com
Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast
to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing …

The Delta SARS-CoV-2 variant of concern induces distinct pathogenic patterns of respiratory disease in K18-hACE2 transgenic mice compared to the ancestral strain …

X Liu, H Mostafavi, WH Ng, JR Freitas, NJC King… - MBio, 2022 - Am Soc Microbiol
Compared to the original ancestral strain of SARS-CoV-2, the Delta variant of concern has
shown increased transmissibility and resistance toward COVID-19 vaccines and therapies …

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

J Lopez, F Anna, P Authié, A Pawlik, MW Ku, C Blanc… - Cell Reports, 2022 - cell.com
Lentiviral vectors (LVs) are highly efficient at inducing CD8+ T cell responses. However, LV-
encoded antigens are processed inside the cytosol of antigen-presenting cells, which does …

K18-and CAG-hACE2 transgenic mouse models and SARS-CoV-2: implications for neurodegeneration research

S Dedoni, V Avdoshina, C Camoglio, C Siddi, W Fratta… - Molecules, 2022 - mdpi.com
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a
global pandemic that might lead to very serious consequences. Notably, mental status …

Integrase deficient lentiviral vector: prospects for safe clinical applications

CHT Yew, N Gurumoorthy, F Nordin, GJ Tye… - PeerJ, 2022 - peerj.com
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic
materials into the targeted cells among many viral vectors. Genetic material transduced by …