The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in
adults, is still largely unknown. The full spectrum of genetic lesions that are present in the …

Squamous cell carcinomas (SCCs) are one of the most frequent forms of human
malignancy, but, other than TP53 mutations, few causative somatic aberrations have been …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently
associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we …

NOTCH1 has been found recurrently mutated in a subset of patients with chronic
lymphocytic leukemia (CLL). To analyze biological features and clinical impact of NOTCH1 …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis …

Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-
ALL), 20% to 30% of patients undergo induction failure (IF) or relapse. Leukemia-initiating …

Although aberrant Notch activation contributes to leukemogenesis in T cells, its role in acute
myelogenous leukemia (AML) remains unclear. Here, we report that human AML samples …