Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Since its inception nearly a half century ago, CHARMM has been playing a central role in
computational biochemistry and biophysics. Commensurate with the developments in …

This review article describes the evolution of Woodward's mechanistic thinking, beginning in
the late 1930s and early 1940s with his proposal of a charge‐transfer mechanism for the …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

Abstract Tandem Diels–Alder reactions are frequently used in the construction of polycyclic
ring systems in complex organic compounds. Unlike the many Diels− Alderases (DAases) …

Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …