The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

HIV/AIDS not only represents the most severe epidemic in modern times, but also the
greatest public health challenge in history. The response of the scientific community has …

Established for 20 years as the definitive virology reference, the two-volume classic Fields
Virology is in its thoroughly revised, updated Fifth Edition. More than 100 world-renowned …

Human immunodeficiency virus (HIV) isolates with reduced sensitivity to zidovudine (3′-
azido-3′-deoxythymidine, AZT) from individuals with acquired immunodeficiency syndrome …

Two ternary complexes of rat DNA polymerase β (pol β), a DNA template-primer, and
dideoxycytidine triphosphate (ddCTP) have been determined at 2.9 Å and 3.6 Å resolution …

EP O701OOO 3, 1996 EP O 701 OOO 1, 2001 WO WO 97.39150 10, 1997 WO
WOO1/23411 4/2001 WO WOO1/32887 5, 2001 WO WO O2/101358 12/2002 WO …

Mutations in HIV-1 reverse transcriptase (RT) give rise to 3′-azido-3′-deoxythymidine
(AZT) resistance by a mechanism that has not been previously reproduced in vitro. We show …

Crystal structures of HIV-1 reverse transcriptase (RT) complexed with a range of chemically
diverse non-nucleoside inhibitors (NNIs) have shown a single pocket in which the inhibitors …

Inhibition constants were determined for 16 nucleoside analog triphosphates against human
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …

HIV-1 replication is inhibited by the incorporation of chain-terminating nucleotides at the 3′
end of the growing DNA chain. Here we show a nucleotide-dependent reaction catalyzed by …