Inflammatory mechanisms in tendinopathy–towards translation

NL Millar, GAC Murrell, IB McInnes - Nature reviews rheumatology, 2017 - nature.com
Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

E Gracey, A Burssens, I Cambré, G Schett… - Nature reviews …, 2020 - nature.com
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

The cellular basis of fibrotic tendon healing: challenges and opportunities

AEC Nichols, KT Best, AE Loiselle - Translational Research, 2019 - Elsevier
Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy

RKW Smith, NJ Werling, SG Dakin, R Alam… - PloS one, 2013 - journals.plos.org
Tendon injuries are a common age-related degenerative condition where current treatment
strategies fail to restore functionality and normal quality of life. This disease also occurs …

High-accuracy positioning in urban environments using single-frequency multi-GNSS RTK/MEMS-IMU integration

T Li, H Zhang, Z Gao, Q Chen, X Niu - Remote sensing, 2018 - mdpi.com
The integration of Global Positioning System (GPS) real-time kinematics (RTK) and an
inertial navigation system (INS) has been widely used in many applications, such as mobile …

Inflammation activation and resolution in human tendon disease

SG Dakin, FO Martinez, C Yapp, G Wells… - Science translational …, 2015 - science.org
Improved understanding of the role of inflammation in tendon disease is required to facilitate
therapeutic target discovery. We studied supraspinatus tendons from patients experiencing …

Are inflammatory cells increased in painful human tendinopathy? A systematic review

BJF Dean, P Gettings, SG Dakin… - British journal of sports …, 2016 - bjsm.bmj.com
Background The role of inflammation in tendinopathy has historically been a subject of
significant controversy. Our primary aim was to determine whether inflammatory cell …

Tendon healing is adversely affected by low-grade inflammation

E Chisari, L Rehak, WS Khan, N Maffulli - Journal of Orthopaedic Surgery …, 2021 - Springer
Background Tendinopathy is common, presents with pain and activity limitation, and is
associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a …

Platelet-rich plasma activates proinflammatory signaling pathways and induces oxidative stress in tendon fibroblasts

JL Hudgens, KB Sugg, JA Grekin… - … American journal of …, 2016 - journals.sagepub.com
Background: Tendon injuries are one of the most common musculoskeletal conditions in
active patients. Platelet-rich plasma (PRP) has shown some promise in the treatment of …

[HTML][HTML] Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy

SG Dakin, J Dudhia, RKW Smith - Veterinary immunology and …, 2014 - Elsevier
Injuries to the superficial digital flexor tendon (SDFT) are an important cause of morbidity
and mortality in equine athletes, but the healing response is poorly understood. One …