As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal
drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well …

Transcription and translation require a high concentration of potassium across the entire tree
of life. The conservation of a high intracellular potassium was an absolute requirement for …

Most proteins assemble into multisubunit complexes. The persistence of these complexes
across evolutionary time is usually explained as the result of natural selection for functional …

The adrenal hormone corticosterone transcriptionally regulates responsive genes in the
rodent hippocampus through nuclear mineralocorticoid and glucocorticoid receptors. Via …

According to Darwinian theory, complexity evolves by a stepwise process of elaboration and
optimization under natural selection. Biological systems composed of tightly integrated parts …

Sodium transport in epithelial tissues is regulated by the physiological mineralocorticoid
aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor …

The last decade has witnessed tremendous progress in the understanding of the
mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for …

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor
(MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads …

Limitations of current steroidal mineralocorticoid receptor (MR) antagonists have stimulated
the search for a new generation of molecules. We screened for novel nonsteroidal …

Glucocorticoids are involved in several responses triggered by a variety of environmental
and physiological stimuli. These hormones have a wide-range of regulatory effects in …