Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

Seizures are often the key manifestation of neurological diseases caused by pathogenic
mutations in 169 of the genes that have so far been identified to affect mitochondrial …

Neuronal activation is fundamental to information processing by the brain and requires
mitochondrial energy metabolism. Mitochondrial Ca2+ uptake by the mitochondrial Ca2+ …

Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, is known to have
anticancer activity, but its underlying mechanism is not completely understood. In this study …

Mitochondria are vital organelles within cells that undertake many important metabolic roles,
the most significant of which is to generate energy to support organ function. Dysfunction of …

Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit
and reduced adenosine triphosphate (ATP) production due to impaired oxidative …

In view of evidence that increased consumption of epicatechin (E) and quercetin (Q) may
reduce the risk of stroke, we have measured the effects of combining E and Q on …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Tau protein plays a pivotal role in the central nervous system (CNS), participating in
microtubule stability, axonal transport, and synaptic communication. Research interest has …

Mitochondria modulate cellular calcium homeostasis by the combined action of the
mitochondrial calcium uniporter (MCU), a selective calcium entry channel, and the sodium …