Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?

C Ling, K Bacos, T Rönn - Nature Reviews Endocrinology, 2022 - nature.com
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Physical activity in the prevention of human diseases: role of epigenetic modifications

E Grazioli, I Dimauro, N Mercatelli, G Wang, Y Pitsiladis… - BMC genomics, 2017 - Springer
Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …

Recent developments on the role of epigenetics in obesity and metabolic disease

SJ van Dijk, RL Tellam, JL Morrison, BS Muhlhausler… - Clinical …, 2015 - Springer
The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …

Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a …

M Sellami, N Bragazzi, MS Prince, J Denham… - Frontiers in …, 2021 - frontiersin.org
Exercise training is one of the few therapeutic interventions that improves health span by
delaying the onset of age-related diseases and preventing early death. The length of …

Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans

J Denham, BJ O'Brien, JT Harvey, FJ Charchar - Epigenomics, 2015 - Taylor & Francis
Aim: DNA methylation programs gene expression and is involved in numerous biological
processes. Accumulating evidence supports transgenerational inheritance of DNA …

A Multi-Center Comparison of O2peak Trainability Between Interval Training and Moderate Intensity Continuous Training

CJ Williams, BJ Gurd, JT Bonafiglia, S Voisin… - Frontiers in …, 2019 - frontiersin.org
There is heterogeneity in the observed O2peak response to similar exercise training, and
different exercise approaches produce variable degrees of exercise response (trainability) …

Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases

NC Gassen, GP Chrousos, EB Binder… - … & Biobehavioral Reviews, 2017 - Elsevier
Life stress has been associated with accelerated cellular aging and increased risk for
developing aging-related diseases; however, the underlying molecular mechanisms remain …

Circulating microRNAs as potential biomarkers of exercise response

M Polakovičová, P Musil, E Laczo, D Hamar… - International journal of …, 2016 - mdpi.com
Systematic physical activity increases physical fitness and exercise capacity that lead to the
improvement of health status and athletic performance. Considerable effort is devoted to …

Physical exercise and the functions of microRNAs

JAC Dos Santos, ASC Veras, VRG Batista… - Life sciences, 2022 - Elsevier
MicroRNAs (miRNAs) control RNA translation and are a class of small, tissue-specific, non-
protein-coding RNAs that maintain cellular homeostasis through negative gene regulation …

Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients

N Celarain, J Tomas-Roig - Journal of neuroinflammation, 2020 - Springer
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous
system characterised by incoordination, sensory loss, weakness, changes in bladder …