The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
A new era for understanding amyloid structures and disease
MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
TO Vogler, JR Wheeler, ED Nguyen, MP Hughes… - Nature, 2018 - nature.com
A dominant histopathological feature in neuromuscular diseases, including amyotrophic
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA …
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA …
Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis
The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …
structural information capable of both propagation and inducing severe neuropathology has …
Biomedical applications of copper ionophores
V Oliveri - Coordination Chemistry Reviews, 2020 - Elsevier
Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
Superoxide dismutase 1 in health and disease: how a frontline antioxidant becomes neurotoxic
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …
Invited Review: The role of prion‐like mechanisms in neurodegenerative diseases
Z Jaunmuktane, S Brandner - Neuropathology and Applied …, 2020 - Wiley Online Library
The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …
characterized by aggregation of abnormally folded conformers of the native prion protein. A …
[HTML][HTML] The role of amyloid oligomers in neurodegenerative pathologies
Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …
possess conformations that spread to healthy proteins. These include Alzheimer's disease …
Intercellular spread of protein aggregates in neurodegenerative disease
AA Davis, CEG Leyns… - Annual review of cell and …, 2018 - annualreviews.org
Most neurodegenerative diseases are characterized by the accumulation of protein
aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in …
aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in …