In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

The developmental dynamics of multicellular organisms is a process that takes place in a
multi-stable system in which each attractor state represents a cell type, and attractor …

One of the most important problems in development is how epigenetic domains can first be
established, and then maintained, within cells. To address this question, we propose a …

It seems that the reception of Conrad Hal Waddington's work never really gathered speed in
mainstream biology. This paper, offering a transdisciplinary survey of approaches using his …

We develop a predictive theoretical model of the physical mechanisms that govern the
heritability and maintenance of epigenetic modifications. This model focuses on a particular …

In eukaryotes, many stable and heritable phenotypes arise from the same DNA sequence,
owing to epigenetic regulatory mechanisms relying on the molecular cooperativity of 'reader …

Abstract How fast? How strong? How many? So what? Why do numbers matter in biology?
Chromatin binding proteins are forever in motion, exchanging rapidly between bound and …

Reconciling the stability of epigenetic patterns with the rapid turnover of histone
modifications and their adaptability to external stimuli is an outstanding challenge. Here, we …

Genomic regions can acquire heritable epigenetic states through unique histone
modifications, which lead to stable gene expression patterns without altering the underlying …