Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

Many short cationic peptides are amphiphilic and are often termed antimicrobial peptides
(AMPs) as they can kill various microorganisms. These AMPs have largely been discovered …

Polymyxins are polycationic antimicrobial peptides that are currently the last-resort
antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The …

Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

Surface tissues of the body such as the skin and intestinal tract are in direct contact with the
external environment and are thus continuously exposed to large numbers of …

Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of
bacterial resistance is a major concern. Here we systematically study the evolution of …

Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a
number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity …

Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …