Therapeutic targeting of intestinal fibrosis in Crohn's disease

G Santacroce, MV Lenti, A Di Sabatino - Cells, 2022 - mdpi.com
Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis

S Peng, L Shen, X Yu, L Zhang, K Xu, Y Xia… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the
colorectal mucosa and submucosa, the incidence of which has been on the rise in recent …

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression-and anxiety-like behaviors via the Nrf2 pathway in mice

J Zhang, L Li, Q Liu, Z Zhao, D Su, C Xiao, T Jin… - Phytomedicine, 2023 - Elsevier
Background Regulating the microglial phenotype is an attractive strategy for treating
diseases of the central nervous system such as depression and anxiety. Gastrodin can …

[HTML][HTML] miR-200a attenuated oxidative stress, inflammation, and apoptosis in dextran sulfate sodium-induced colitis through activation of Nrf2

S Peng, L Shen, X Yu, J Wu, L Zha, Y Xia… - Frontiers in …, 2023 - frontiersin.org
Introduction Oxidative stress and inflammatory responses are critical factors in ulcerative
colitis disease pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) modulates …

Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis

W Tian, H Wang, Y Zhu, Q Wang, M Song, Y Cao… - Journal of Controlled …, 2022 - Elsevier
The emerging concept that “the maximized therapeutic efficacy of encapsulates would be
achieved by inducing appropriate absorption site and pharmacological signal pathways …

Ambroxol, a mucolytic agent, boosts HO‐1, suppresses NF‐κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for …

S Cavalu, H Sharaf, S Saber, ME Youssef… - The FASEB …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that
increases the risk of developing colorectal cancer and imposes a lifelong healthcare burden …

Single-cell expression atlas reveals cell heterogeneity in the creeping fat of Crohn's disease

W Shu, Y Wang, C Li, L Zhang… - Inflammatory Bowel …, 2023 - academic.oup.com
Abstract Background Creeping fat (CrF) has been recognized to play a positive role in
Crohn's disease (CD) progression, yet the cellular compositions within mesenteric adipose …

System biology analysis to develop diagnostic biomarkers, monitoring pathological indexes, and novel therapeutic approaches for immune targeting based on maggot …

E Kaviani, F Hajibabaie, N Abedpoor, K Safavi… - Environmental …, 2023 - Elsevier
Early diagnosis and prognosis are prerequisites for mitigating mortality in gastric cancer
(GaCa). Identifying some causative or sensitive elements (coding RNA (cRNA)-non-cRNAs …

[HTML][HTML] Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease

B Li, Y Wang, X Jiang, H Du, Y Shi, M Xiu, Y Liu… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which
is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a …

SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation

X Xue, X Zeng, X Wu, K Mu, Y Dai, Z Wei - Matrix Biology, 2023 - Elsevier
Intestinal fibrosis is a prevalent complication of Crohn's disease (CD), characterized by
excessive deposition of extracellular matrix (ECM), and no approved drugs are currently …