Vitamin D is a critical regulator of calcium and bone homeostasis. While vitamin D has
multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) …

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

Nephrolithiasis is a worldwide problem with increasing prevalence, enormous costs, and
significant morbidity. Calcium-containing kidney stones are by far the most common kidney …

Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …

Epithelial calcium channel TRPV6 is a member of the vanilloid subfamily of TRP channels
that is permeable to cations and highly selective to Ca2+; it shows constitutive activity …

Calcium absorption and secretion can occur along the length of the small and large
intestine. To date, the focus of research into intestinal calcium absorption has been the small …

TRPV6 is a Transient Receptor Potential Vanilloid (TRPV) cation channel with high
selectivity for Ca 2+ ions. First identified in 1999 in a search for the gene which mediates …

Introduction. TRPVs are a group of receptors with a channel activity predominantly
permeable to Ca2+. This subfamily is involved in the development of gastrointestinal …

Calcium is required for the functioning of numerous biological processes and is essential for
skeletal health. The major source of new calcium is from the diet. The central role of vitamin …