Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Autophagy captures intracellular components and delivers them to lysosomes, where they
are degraded and recycled to sustain metabolism and to enable survival during starvation …

Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

Background Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC
often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG …

Highlights•Reviewed the function of arginine and its metabolites in arginine deprivation
therapy.•Discussed the difference of arginine deiminase and recombinant human arginase …

Difference in the metabolism of normal and cancer cells inspires to search for new, more
specific and less toxic therapies than those currently used. The development of tumors is …

Importance Preclinical studies show that arginine deprivation is synthetically lethal in
argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma. The role …