Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …

GABA and GABAA-receptors (GABAA-Rs) play major roles in neurodevelopment and
neurotransmission in the central nervous system (CNS). There has been a growing …

With a new generation of antibody-drug conjugates (ADCs) that contain a drug-to-antibody
ratio (DAR) of 2, the question remains whether advances in technology have resulted in …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …

Introduction Microglia is the resident tissue macrophages of the central nervous system.
Prolonged microglial activation often occurs after traumatic brain injury and is associated …

Benzodiazepines, psychotropics drugs used for treating sleep disorders, anxiety and
epilepsy, represent a major class of emerging water pollutants. As occurs for other …

Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE)
cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the …