Cell-type deconvolution from DNA methylation: a review of recent applications

AJ Titus, RM Gallimore, LA Salas… - Human molecular …, 2017 - academic.oup.com
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

[PDF][PDF] Forensic individual age estimation with DNA: from initial approaches to methylation tests

A Freire-Aradas, C Phillips… - Forensic Sci Rev, 2017 - forensicsciencereview.com
Individual age estimation is a key factor in forensic science analysis that can provide very
useful information applicable to criminal, legal, and anthropological investigations. Forensic …

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma

SE Reese, CJ Xu, HT Den Dekker, MK Lee… - Journal of Allergy and …, 2019 - Elsevier
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

RH Mulder, A Neumann, CAM Cecil… - Human molecular …, 2021 - academic.oup.com
DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …

[HTML][HTML] Nasal DNA methylation at three CpG sites predicts childhood allergic disease

M van Breugel, C Qi, Z Xu, CET Pedersen… - Nature …, 2022 - nature.com
Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions
that share strong genetic and environmental components. Diagnosis relies on clinical history …

[HTML][HTML] Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of …

FW Lohoff, TK Clarke, ZA Kaminsky, RM Walker… - Molecular …, 2022 - nature.com
Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …

[HTML][HTML] Multi-omics approaches in immunological research

X Chu, B Zhang, VACM Koeken, MK Gupta… - Frontiers in …, 2021 - frontiersin.org
The immune system plays a vital role in health and disease, and is regulated through a
complex interactive network of many different immune cells and mediators. To understand …

The role of epigenetics in the development of childhood asthma

C Qi, CJ Xu, GH Koppelman - Expert review of clinical immunology, 2019 - Taylor & Francis
Introduction: The development of childhood asthma is caused by a combination of genetic
factors and environmental exposures. Epigenetics describes mechanisms of (heritable) …

The role of DNA methylation in personalized medicine for immune-related diseases

MK Gupta, H Peng, Y Li, CJ Xu - Pharmacology & Therapeutics, 2023 - Elsevier
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …