Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and
maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF …

Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Thoracic aortic aneurysms that progress to acute aortic dissections are often fatal. Thoracic
aneurysms have been managed with treatment with β-adrenergic blocking agents (β …

The development and pathogenesis of atherosclerosis are significantly influenced by
lifestyle, particularly nutrition. The modern level of science and technology development …

Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Objective—Recent evidence suggests an important role for angiotensin-converting enzyme
2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of …

Connective tissue is known to provide structural and functional “glue” properties to other
tissues. It contains cellular and molecular components that are arranged in several dynamic …

e60 Arterioscler Thromb Vasc Biol June 2017 also one important feature of asthma. A recent
study reported an association between active asthma and AAA in humans. 15 This group …

Cancer and inflammatory disorders are two important public health issues worldwide with
significant socioeconomic impacts. Despite several efforts, the current therapeutic platforms …