Reactive astrocytes undergo morphological, molecular, metabolic, and functional
remodeling in response to central nervous system (CNS) damage. However, we still know …

Astrocytes, a class of morphologically and functionally diverse primary homeostatic
neuroglia, are key keepers of neural tissue homeostasis and fundamental contributors to …

An emerging picture suggests that glial cells' loss of beneficial roles or gain of toxic functions
can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes …

Mild traumatic brain injury (mTBI) disproportionately affects military service members and is
very difficult to diagnose. To-date, there is currently no blood-based, diagnostic biomarker …

Mitochondrial function has long been the focus of many therapeutic strategies for
ameliorating age-related neurodegeneration and cognitive decline. Historically, the role of …

Understanding the regulation of axon growth after injury to the adult central nervous system
(CNS) is crucial to improve neural repair. Following acute focal CNS injury, astrocytes are …

Targeted protein degradation (TPD) has emerged as an effective therapeutic strategy for a
wide range of diseases; however, the blood-brain barrier (BBB) limits access of degraders …

Neuromyelitis optica is an autoimmune inflammatory disorder targeting aquaporin-4 water
channels in CNS astrocytes. Histopathological descriptions of astrocytic lesions reported in …

Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-
pathological features of tauopathies. Although tau protein is highly enriched in neurons and …

Background Microglia colonize the developing vertebrate central nervous system coincident
with the detection of developmental apoptosis. Our understanding of apoptosis in intact …