Cancer stem cells and chemoresistance: The smartest survives the raid

J Zhao - Pharmacology & therapeutics, 2016 - Elsevier
Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

The regulatory role of microRNAs in EMT and cancer

A Zaravinos - Journal of oncology, 2015 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis

S Su, Q Liu, J Chen, J Chen, F Chen, C He, D Huang… - Cancer cell, 2014 - cell.com
The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and
tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these …

Exosome-mediated breast cancer chemoresistance via miR-155 transfer

JC Santos, NS Lima, LO Sarian, A Matheu… - Scientific reports, 2018 - nature.com
Breast cancer remains the most prevalent cause of cancer mortality in woman worldwide
due to the metastatic process and therapy resistance. Resistance against cancer therapy is …

[HTML][HTML] Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer

KA Hyun, GB Koo, H Han, J Sohn, W Choi, SI Kim… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The dissemination of circulating tumor cells (CTCs) requires the Epithelial-to-Mesenchymal
transition (EMT), in which cells lose their epithelial characteristics and acquire more …

Chitosan-decorated doxorubicin-encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem-like cells

W Rao, H Wang, J Han, S Zhao, J Dumbleton… - ACS …, 2015 - ACS Publications
Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated
with conventional chemotherapy. We developed a doxorubicin-encapsulated polymeric …

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

G Lazzari, P Couvreur, S Mura - Polymer Chemistry, 2017 - pubs.rsc.org
The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …

Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways

G Leon, L MacDonagh, SP Finn, S Cuffe… - Pharmacology & …, 2016 - Elsevier
Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-
cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year …

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

S Delaunay, F Rapino, L Tharun, Z Zhou… - Journal of Experimental …, 2016 - rupress.org
Quantitative and qualitative changes in mRNA translation occur in tumor cells and support
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs …

Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT

C Hu, M Li, T Guo, S Wang, W Huang, K Yang, Z Liao… - Phytomedicine, 2019 - Elsevier
Background Curcumin is a polyphenolic compound with potent chemopreventive and anti-
cancer efficacy. Purpose To explore the potential anti-metastasis efficacy of curcumin in …