OBJECTIVE: After prolonged opioid exposure, children develop opioid-induced
hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should …

Propofol is an intravenous short‐acting anesthetic widely used to induce and maintain
general anesthesia and to provide procedural sedation. The potential for propofol …

Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …

The prevention and management of malaria is primarily based on the use of drugs. Clinical
trials have however revealed that between individuals there is large variability in the …

Aim: Hepatic enzymes, CYP2B6 and UGT2B7 play a major role in the metabolism of the
widely used antiretroviral drugs efavirenz, nevirapine and zidovudine. In the present study …

The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …

Objective Interindividual variability in analgesic response and adverse effects of opioids
because of narrow therapeutic indices are major clinical problems. Morphine is an opioid …

Objective UDP-glucuronosyltransferase 2B7 (UGT2B7) plays a central role in the liver-
mediated biotransformation of endogenous and exogenous compounds. The genetic basis …

Objectives This study was conducted to assess inter-species and inter-individual differences
in the metabolism of di (2-ethylhexyl) phthalate (DEHP) in humans and mice. Methods The …

What is already known about this subject• The novel CYP2B6 functional polymorphism
983T> C (either alone as CYP2B6* 18 or linked with 785A> G as the CYP2B6* 16 allele) …