Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Purpose Despite the beneficial effects of chemotherapy, therapy-induced senescence (TIS)
manifests itself as an undesirable byproduct. Preclinical evidence suggests that tumor cells …

Aberrant B-cell receptor/NF-κB signaling is a hallmark feature of B-cell non-Hodgkin
lymphomas, especially in diffuse large B-cell lymphoma (DLBCL). Recurrent mutations in …

Anticancer therapies can induce cellular senescence or drug-tolerant persistence, two types
of proliferative arrest that differ in their stability. While senescence is highly stable, persister …

Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

Multiple molecular features, such as activation of specific oncogenes (eg, MYC, BCL2) or a
variety of gene expression signatures, have been associated with disease course in diffuse …