Obesity is a major health problem contributing to increased subfertility in males, as well as
increased morbidity for diseases related to a decline in testosterone production with aging …

Unresectable glioblastoma (GBM) cells in the invading tumor edge can act as seeds for
recurrence. The molecular and phenotypic properties of these cells remain elusive. Here, we …

Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of
conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs …

Rationale: Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on
their metabolic state and gene expression profile, features influenced by contact with …

Retention of critical endoplasmic reticulum (ER) luminal proteins needed to carry out diverse
functions (eg, protein synthesis and folding, lipid metabolism) is mediated through a carboxy …

Transcription factors are important gene regulators with distinctive roles in development, cell
signaling and cell cycling, and they have been associated with many diseases. The ConTra …

Local interactions between cancer cells and stroma can produce systemic effects on distant
organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of …

Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated
gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory …

There is growing evidence that the p53 tumour suppressor downregulates vascular
endothelial growth factor (VEGF) expression, although the underlying mechanisms remain …

The epithelial to mensenchymal transition program regulates various aspects of embryonic
development and tissue homeostasis, but aberrant activation of this pathway in cancer …