The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

Extensive population‐based studies are much needed to accurately establish epidemiology
and disease course in patients with primary sclerosing cholangitis (PSC). We aimed to …

1 ESGE/EASL recommend that, as the primary diagnostic modality for PSC, magnetic
resonance cholangiography (MRC) should be preferred over endoscopic retrograde …

Background & Aims: Patients with ulcerative colitis are at increased risk of colorectal cancer.
It is widely believed that this is secondary to colonic inflammation. However, the severity of …

Background: Inflammatory bowel disease associated with primary sclerosing cholangitis
(PSC-IBD) may have a high prevalence of rectal sparing, backwash ileitis, and colorectal …

Background Patients with ulcerative colitis (UC) have an increased risk of developing
colorectal cancer (CRC); however, the magnitude of this effect is open to debate. Aim To …

Background & Aims: The value of colonoscopic surveillance for neoplasia in long-standing
extensive ulcerative colitis remains controversial. This study reports on prospectively …

Background: Published data on the risk of colorectal neoplasia in patients with ulcerative
colitis with and without primary sclerosing cholangitis are conflicting. A meta-analysis was …

The risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated,
and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of …