Optical-based biosensor for detection of oncomarker CA 125, recent progress and current status

AV Yumashev, M Rudiansyah, S Chupradit… - Analytical …, 2022 - Elsevier
Ovarian cancer (OV) is the second most mortal gynecological malignancy. The oncomarker
CA125 has been used as the main ovarian cancer marker for diagnosing and screening …

Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics

F Ferrara, S Zoupanou, E Primiceri, Z Ali… - Biosensors and …, 2022 - Elsevier
Liquid biopsy technologies have seen a significant improvement in the last decade, offering
the possibility of reliable analysis and diagnosis from several biological fluids. The use of …

Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes

AH Ren, PS Filippou, A Soosaipillai… - Clinical Chemistry and …, 2023 - degruyter.com
Objectives Ovarian cancer is the most lethal gynecological malignancy in developed
countries. One of the key associations with the high mortality rate is diagnosis at late stages …

A matrix metalloproteinase sensing biosensor for the evaluation of chronic wounds

SM Kang, H Cho, D Jeon, SH Park, DS Shin, CY Heo - BioChip Journal, 2019 - Springer
The increasing prevalence of the elderly in global society is being accompanied by rapidly
increasing numbers of patients with cerebrovascular disease or diabetes, and patients with …

Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases

PS Filippou, AH Ren, D Korbakis… - Clinical Chemistry and …, 2018 - degruyter.com
Abstract Background: Mucin 13 (MUC13) is a cell surface glycoprotein aberrantly expressed
in a variety of epithelial carcinomas. Thus far, the role of MUC13 in various diseases …

Optical fingerprints of proteases and their inhibited complexes provided by differential cross-reactivity of fluorophore-labeled single-stranded DNA

S Tomita, H Sugai, M Mimura, S Ishihara… - … applied materials & …, 2019 - ACS Publications
The detection of proteases and their complexes with inhibitor proteins is of great importance
for diagnosis and medical-treatment applications. In this study, we report a fingerprint-based …

Wearable Sweat Management Technologies

L Wei, Z Li, Z Dai, L Ding, H Wei, J Li… - Advanced Materials …, 2024 - Wiley Online Library
The aging population and increasing prevalence of diseases among younger individuals
have heightened the pressing demand for wearable health monitoring devices among the …

Kallikrein-related peptidases protein expression in lymphoid tissues suggests potential implications in immune response

PS Filippou, AH Ren, A Soosaipillai, R Safar… - Clinical …, 2020 - Elsevier
Abstract Objectives Kallikrein-related peptidases (KLKs) are a subgroup of 15 secreted
chymotrypsin-and trypsin-like serine proteases that have been reported to possess novel …

Detection of antibody-conjugate payload in cynomolgus monkey serum by a high throughput capture LC–MS/MS bioanalysis method

S Wang, F Wang, L Wang, Z Liu, M Liu, S Li… - … of Pharmaceutical and …, 2023 - Elsevier
Antibody-drug conjugate (ADC) plays a vital role in oncology indications. The efficacy and
toxicity of ADC generally depend on the concentration of the drugs in the body system, and …

Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer

PS Filippou, AH Ren, S Bala, MD Papaioannou… - Clinical …, 2018 - Elsevier
Objective Human tissue kallikrein 15 (KLK15) is the last cloned member of the KLK-related
gene family. Despite being implicated in multiple cancers, its pathophysiological role …