Heart failure (HF) is a chronic, complex condition with increasing incidence worldwide,
necessitating the development of novel therapeutic strategies. This has led to the current …

Background Heart failure (HF) is a condition characterized by the heart's inability to meet the
body's demands, resulting in various complications. Two primary types of HF exist, namely …

Background Cardiac fibroblasts (CFs) have the ability to sense stiffness changes and
respond to biochemical cues to modulate their states as either quiescent or activated …

Abstract Protocatechuic acid (3, 4‐dihydroxybenzoic acid) prevents oxidative stress,
inflammation and cardiac hypertrophy. This study aimed to investigate the therapeutic effects …

Heart failure is the common final pathway of several cardiovascular conditions and a major
cause of morbidity and mortality worldwide. Aberrant activation of the adaptive immune …

Oxidative stress and renal inflammation play a pivotal role in the pathogenesis of
hypertension. The redox-sensitive transcription factor, nuclear factor E2-related factor 2 …

Heart failure is a leading cause of death and is often accompanied by activation of quiescent
cardiac myofibroblasts, which results in cardiac fibrosis. In this study, we aimed to identify …

Rationale: The major cause of heart failure is myocardium death consequent to detrimental
cardiac remodeling and fibrosis following myocardial infarction. The cardiac protective …

Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms.
Here, we find that increased plasma tyrosine and phenylalanine levels are associated with …

Hyperactivity of the sympathetic nervous system is a major driver of cardiac remodeling,
exerting its effects through both α-, and β-adrenoceptors (α-, β-ARs). As the relative …