Epigenetic dysregulation has long been recognized as a key factor contributing to
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Within the cell nucleus, the organization of the eukaryotic DNA into chromatin uses histones
as components of its building block, the nucleosome. This chromatin organization …

Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet
the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone …

Targeting glycolysis has been considered therapeutically intractable owing to its essential
housekeeping role. However, the context-dependent requirement for individual glycolytic …

Tumor-infiltrating CD8+ T cells progressively lose functionality and fail to reject tumors. The
underlying mechanism and re-programing induced by checkpoint blockers are incompletely …

TGF-β signaling is fundamental for both Th17 and regulatory T (Treg) cell differentiation.
However, these cells differ in requirements for downstream signaling components, such as …

For treatment of glioblastoma (GBM), temozolomide (TMZ) and radiotherapy (RT) exert
antitumor effects by inducing DNA double-strand breaks (DSBs), mainly via futile DNA …

DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …

Cell fate commitment is driven by dynamic changes in chromatin architecture and activity of
lineage-specific transcription factors (TFs). The chromatin assembly factor-1 (CAF-1) is a …