Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …

Contraction of both skeletal muscle and the heart is thought to be controlled by a calcium-
dependent structural change in the actin-containing thin filaments, which permits the binding …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Recent studies have demonstrated a role for the elastic protein titin in active muscle, but the
mechanisms by which titin plays this role remain to be elucidated. In active muscle, Ca2+ …

In striated muscles, the rapid production of macroscopic levels of force and displacement
stems directly from highly ordered and hierarchical protein organization, with the sarcomere …

Titin constitutes the third myofilament of cardiac muscle, with a single giant polypeptide
spanning from the Z disk to the M-band region of the sarcomere1 (Figure 1). The 1.0-MDa …