Proneurotrophins were initially thought to be simple inactive precursors, only responsible for
promoting the folding of the mature domain and for the regulation of the neurotrophin …

Neurotrophins constitute a family of growth factors that play a key role in the regulation of the
development and function of the central and peripheral nervous systems. A common feature …

Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity,
induces apoptosis and is associated with mental disorders. The detailed structure of SorCS2 …

Neurotrophin receptors mediate a plethora of signals affecting neuronal survival. The p75
pan-neurotrophin receptor controls neuronal cell fate after its selective activation by …

Фактору роста нервов (Nerve Growth Factor–NGF) принадлежит ключевая роль в
осуществлении нейропластичности, формировании поведенческих реакций …

Simple Summary A point mutation in the Nerve Growth factor gene (leading to the amino
acid substitution R100W), causing Hereditary Sensory and Autonomic Neuropathy type V, a …

Despite constituting nearly a quarter of the existing proteome, membrane proteins remain
some of the most challenging biological molecules to isolate for biochemical and structural …

Alzheimer's disease is underscored by the degeneration of basal forebrain cholinergic
neurons (BFCNs). The survival and function of BFCNs depends on nerve growth factor …

Abstract p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural
crest marker. It has been reported that p75NTR not only played an important role in the …

Proneurotrophins were initially thought to be simple inactive precursors, only responsible for
promoting the folding of the mature domain and for the regulation of the neurotrophin …