Since epidemiologic data have highlighted the positive effects of metformin to reduce cancer
incidence and mortality, many in vitro and in vivo studies as well as a large number of …

Oxidative stress results from an imbalance between reactive oxygen species (ROS)
production and antioxidant defense mechanisms. The regulation of stem cell self‐renewal …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

During growth, homeostasis and regeneration, stem cells are exposed to different energy
demands. Here, we characterise the metabolic pathways that mediate the commitment and …

Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with self-
renewal capacity and are considered as an underlying cause of tumor recurrence and …

When fighting cancer, knowledge on metabolism has always been important. Today, it
matters more than ever. The restricted cataloging of cancer genomes is quite unlikely to …

The acquisition of and departure from stemness in cancer tissues might not only be
hardwired by genetic controllers, but also by the pivotal regulatory role of the cellular …

Energy metabolism plasticity enables stemness programs during the reprogramming of
somatic cells to an induced pluripotent stem cell (iPSC) state. This relationship may …

Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the
archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) …

Engineering pluripotency through nuclear reprogramming and directing stem cells into
defined lineages underscores cell fate plasticity. Acquisition of and departure from stemness …