Context: Continuous processing is an innovative production concept well known and
successfully used in other industries for many years. The modern pharmaceutical industry is …

Large-scale fluid bed coating operations using Wurster coaters are common in the
pharmaceutical industry. Experimental measurements of the coating thickness are usually …

A vertical in-line continuous powder mixing device (CMT–Continuous Mixing Technology)
has been modelled with the discrete element method (DEM) utilizing a calibrated cohesive …

Simulations of granular flow of monodisperse, cohesionless spherical glass beads in a
cylindrical bladed mixer agitated by an impeller were performed using the discrete element …

The material properties of excipients and active pharmaceutical ingredients (API's) are
important parameters that affect blend uniformity of pharmaceutical powder formulations …

The goal of this work is an comprehensive experimental validation and verification of a
computational CFD-DEM software platform. The software platform's modules and …

Flow of cohesive granular materials with different moisture contents was examined in a four-
bladed mixer via the discrete element method (DEM). Firstly, the mixer diameter (D) was …

Transferring an existing marketed pharmaceutical product from batch to continuous
manufacturing (CM) without changes in regulatory registration is a challenging task in the …

The large-scale industrial drums have a considerable number of material particles rotating in
them, reaching 10 9 or more. This causes a large particle system; it is difficult to carry out a …

The presence of powder agglomerates results in product with poor content uniformity and
intermittent high potency in the processing of pharmaceutical powders. We developed a …