In 2016, sepsis was newly defined as life-threatening organ dysfunction caused by a
dysregulated host response to infection. Sepsis remains one of the crucial medical problems …

Histidine-rich glycoprotein (HRGP) is a relatively less known glycoprotein, but it is abundant
in plasma with a multidomain structure, which allows it to interact with many ligands and …

Background Hepatocellular carcinoma (HCC) is the main histological subtype of liver
cancer, which has the characteristics of poor prognosis and high fatality rate. Single-cell …

Abstract Coronavirus disease-2019 (COVID-19) provokes a hypercoagulable state with
increased incidence of thromboembolism and mortality. Platelets are major effectors of …

Abstract Cystatin C (Cst-3) is a potent inhibitor of cysteine proteases with diverse biological
functions. As a secreted protein, the potential interaction between Cst-3 and extracellular …

Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike
other flaviviruses, ZIKV can be sexually transmitted by vaginal intercourse. The healthy …

Background Histidine-rich glycoprotein (HRG), a potential prognostic factor in sepsis, lacks
clarity regarding its relevance in septic-induced shock, disseminated intravascular …

The antiangiogenic activity of the H/P domain of histidine–proline-rich glycoprotein is
mediated by its binding with tropomyosin, a protein exposed on endothelial cell-surface …

Heparan sulfate (HS) is polysaccharide that is expressed by all mammalian nucleated cells.
It is found on the cell membrane and in the extracellular matrix as part of HS proteoglycans …