Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products

R Batista, A De Jesus Silva Júnior, AB De Oliveira - Molecules, 2009 - mdpi.com
Malaria is still the most destructive and dangerous parasitic infection in many tropical and
subtropical countries. The burden of this disease is getting worse, mainly due to the …

Coumarin–chalcone hybrids: promising agents with diverse pharmacological properties

H Wei, J Ruan, X Zhang - RSC advances, 2016 - pubs.rsc.org
Naturally and synthetically derived hybrid molecules are an attractive source for therapeutic
agent development due to their dual or multiple modes of action and other advantages …

Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro

N Yadav, SK Dixit, A Bhattacharya… - Chemical biology & …, 2012 - Wiley Online Library
Twenty‐seven novel chalcone derivatives were synthesized using Claisen‐Schmidt
condensation and their antimalarial activity against asexual blood stages of Plasmodium …

In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

S Sinha, DI Batovska, B Medhi, BD Radotra, A Bhalla… - Malaria Journal, 2019 - Springer
Background Malaria extensively leads to mortality and morbidity in endemic regions, and the
emergence of drug resistant parasites is alarming. Plant derived synthetic pharmaceutical …

Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

F Kayamba, T Malimabe, IK Ademola, OJ Pooe… - European Journal of …, 2021 - Elsevier
Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of
Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant …

Biological effects of licochalcones

GD Maria Pia, F Sara, F Mario… - Mini reviews in …, 2019 - ingentaconnect.com
Medicinal plants and their natural bioactive molecules, are evaluated as the foundation for
health preservation and care of humanity. The licorice root, known as “Radix Glycyrrhizae” …

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349

X Su, T Li, Z Liu, Q Huang, K Liao, R Ren, L Lu… - Free Radical Biology …, 2018 - Elsevier
Licochalcone A (LCA) is derived from glycyrrhizae radix with antimicrobial, antitumor and
anti-inflammatory activities. However, the anti-arthritic function of LCA and underlying …

Natural phenolic compounds and derivatives as potential antimalarial agents

L Mamede, A Ledoux, O Jansen, M Frédérich - Planta medica, 2020 - thieme-connect.com
Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for
hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent …

Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine …

M Feldman, D Grenier - Journal of applied microbiology, 2012 - academic.oup.com
Aims: Periodontitis is an inflammatory disease of polymicrobial origin that affects the tooth‐
supporting tissues. With the spread of antibiotic resistance among pathogenic bacteria …

[HTML][HTML] Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells

MK Park, J Ji, K Haam, TH Han, S Lim, MJ Kang… - Biomedicine & …, 2021 - Elsevier
Abstract Hypoxia-inducible factor (HIF)-1 is an important regulator of the cellular response in
the hypoxic tumor environment. While searching for HIF inhibitors derived from natural …