Harnessing endogenous stimuli for responsive materials in theranostics

AB Cook, P Decuzzi - ACS nano, 2021 - ACS Publications
Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Insights into active targeting of nanoparticles in drug delivery: advances in clinical studies and design considerations for cancer nanomedicine

AK Pearce, RK O'Reilly - Bioconjugate chemistry, 2019 - ACS Publications
Nanomedicine is a promising strategy for improving clinical outcomes for cancer therapies,
by improving drug efficacy through enhanced delivery to disease sites. It is of importance for …

Stimulus-responsive self-assembled prodrugs in cancer therapy

X Dong, RK Brahma, C Fang, SQ Yao - Chemical science, 2022 - pubs.rsc.org
Small-molecule prodrugs have become the main toolbox to improve the unfavorable
physicochemical properties of potential therapeutic compounds in contemporary anti-cancer …

Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting

MA Rahim, N Jan, S Khan, H Shah, A Madni, A Khan… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the leading causes of death globally. Several studies,
efforts and treatment strategies have been put forth for the treatment of different types of …

Doxorubicin prodrug-based nanomedicines for the treatment of cancer

H Zhao, J Yu, R Zhang, P Chen, H Jiang… - European journal of …, 2023 - Elsevier
The chemotherapeutic drug of doxorubicin (DOX) has witnessed widespread applications
for treating various cancers. DOX-treated dying cells bear cellular modifications which allow …

Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Microsatellite instability: diagnosis, heterogeneity, discordance, and clinical impact in colorectal cancer

C Evrard, G Tachon, V Randrian, L Karayan-Tapon… - Cancers, 2019 - mdpi.com
Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Applications of the ROS-responsive thioketal linker for the production of smart nanomedicines

A Rinaldi, R Caraffi, MV Grazioli, N Oddone, L Giardino… - Polymers, 2022 - mdpi.com
Reactive oxygen species (ROS)-sensitive drug delivery systems (DDS) specifically
responding to altered levels of ROS in the pathological microenvironment have emerged as …

Camptothecin-based prodrug nanomedicines for cancer therapy

R Zhang, J Yu, Z Guo, H Jiang, C Wang - Nanoscale, 2023 - pubs.rsc.org
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide-spectrum antitumour …

Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: Recent advances

H Phan, V Taresco, J Penelle, B Couturaud - Biomaterials Science, 2021 - pubs.rsc.org
Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers
for enhancing site-specific and on-demand drug release in response to a range of stimuli …