Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages
Understanding cell state transitions and purposefully controlling them to improve therapies
is a longstanding challenge in biological research and medicine. Here, we identify a …
is a longstanding challenge in biological research and medicine. Here, we identify a …
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
A quarter of human population is infected with Mycobacterium tuberculosis, but less than
10% of those infected develop pulmonary TB. We developed a genetically defined sst1 …
10% of those infected develop pulmonary TB. We developed a genetically defined sst1 …
Aberrant macrophage activation and failed regeneration of pulmonary epithelium promote tuberculosis progression uniquely in lung tissue
Pulmonary TB that develops in immunocompetent adult humans is responsible for
approximately 85% of the disease burden and is central for Mtb transmission. Most humans …
approximately 85% of the disease burden and is central for Mtb transmission. Most humans …