Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

Evidence has been building that the pathologic drive for development of osteoarthritis (OA)
involves more than simple mechanical “wear and tear.” Inflammatory mechanisms play an …

Osteoarthritis (OA) is the most common form of degenerative arthritis, mainly characterized
by the degradation of articular cartilage and associated with subchondral bone lesions …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …

Tissue regeneration using stem cell-based transplantation faces many hurdles. Alternatively,
therapeutically exploiting endogenous stem cells to regenerate injured or diseased tissue …

Objectives The heterogeneity of meniscus cells and the mechanism of meniscus
degeneration is not well understood. Here, single-cell RNA sequencing (scRNA-seq) was …

Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of
cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and …

The meniscus is the most commonly injured structure in the human knee. Meniscus
deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal …