Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment

N Samsu - BioMed research international, 2021 - Wiley Online Library
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Macrophages: versatile players in renal inflammation and fibrosis

PMK Tang, DJ Nikolic-Paterson, HY Lan - Nature Reviews Nephrology, 2019 - nature.com
Macrophages have important roles in immune surveillance and in the maintenance of
kidney homeostasis; their response to renal injury varies enormously depending on the …

Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets

W Lv, GW Booz, Y Wang, F Fan, RJ Roman - European journal of …, 2018 - Elsevier
Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

Diabetic nephropathy: a tangled web to unweave

C Magee, DJ Grieve, CJ Watson, DP Brazil - Cardiovascular drugs and …, 2017 - Springer
Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease
globally. Given the increasing incidence of diabetes, many experts hold the view that DN will …

Acute kidney injury and progression of diabetic kidney disease

SMW Yu, JV Bonventre - Advances in chronic kidney disease, 2018 - Elsevier
Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Urinary biomarkers in the assessment of early diabetic nephropathy

C Gluhovschi, G Gluhovschi, L Petrica… - Journal of diabetes …, 2016 - Wiley Online Library
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM).
Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis …

microRNA crosstalk influences epithelial-to-mesenchymal, endothelial-to-mesenchymal, and macrophage-to-mesenchymal transitions in the kidney

SP Srivastava, AF Hedayat, K Kanasaki… - Frontiers in …, 2019 - frontiersin.org
microRNAs (miRNAs) are small, non-coding nucleotides that regulate diverse biological
processes. Altered microRNA biosynthesis or regulation contributes to pathological …

Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease

J Guo, Z Liu, R Gong - Clinical Science, 2019 - portlandpress.com
Diabetic kidney disease (DKD) is among the most common complications of diabetes
mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in …

Insights into predicting diabetic nephropathy using urinary biomarkers

NU Khan, J Lin, X Liu, H Li, W Lu, Z Zhong… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Diabetic nephropathy (DN) is a serious complication of diabetes caused by changes in the
structure and function of the kidneys. It is important to detect diagnostic biomarkers of DN at …

Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy

X Jiang, J Yu, X Wang, J Ge, N Li - Diabetes, Metabolic Syndrome …, 2019 - Taylor & Francis
Purpose: Quercetin, the most widely distributed flavonoid, has been shown to have multiple
properties and beneficial effects on various metabolic diseases. Thus, our aim was to …