The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …

Aldehyde dehydrogenases 1 family member A1 (ALDH1A1) gene codes a cytoplasmic
enzyme and shows vital physiological and pathophysiological functions in many areas …

Abstract Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …

The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single …

As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …

Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in
Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from …

Parkinson's disease is the second most common neurodegenerative disease. Unfortunately,
there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian …

Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc DA) inhibit
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …