Selecting the optimal immunotherapy regimen in driver-negative metastatic NSCLC

MJ Grant, RS Herbst, SB Goldberg - Nature reviews Clinical oncology, 2021 - nature.com
The treatment landscape of driver-negative non-small-cell lung cancer (NSCLC) is rapidly
evolving. Immune-checkpoint inhibitors, specifically those targeting PD-1 or PD-L1, have …

Targeted toxicities: Protocols for monitoring the adverse events of targeted therapies used in the treatment of non-small cell lung cancer

JB Hines, B Bowar, E Levine, A Esposito… - International Journal of …, 2023 - mdpi.com
Targeted therapies have revolutionized the treatment for many patients with non-small cell
lung cancer (NSCLC). Multiple new oral targeted therapies have been approved in the last …

[HTML][HTML] Lung cancer in Vietnam

HTT Tran, S Nguyen, KK Nguyen, DX Pham… - Journal of Thoracic …, 2021 - Elsevier
Vietnam, a low–middle-income Southeast Asian country with a population of 96.5 million, is
the 15th most populous country in the world. 1 In 1986, the Vietnamese Government …

[HTML][HTML] Predicting oncogene mutations of lung cancer using deep learning and histopathologic features on whole-slide images

N Tomita, LJ Tafe, AA Suriawinata, GJ Tsongalis… - Translational …, 2022 - Elsevier
Lung cancer is a leading cause of death in both men and women globally. The recent
development of tumor molecular profiling has opened opportunities for targeted therapies for …

Real‐world utility of next‐generation sequencing for targeted gene analysis and its application to treatment in lung adenocarcinoma

JH Kim, S Yoon, DH Lee, SJ Jang, SM Chun… - Cancer …, 2021 - Wiley Online Library
Purpose This study investigated the clinical utility of next‐generation sequencing (NGS) for
detection of genetic alterations and its implications on treatment of lung adenocarcinoma in …

[HTML][HTML] Next-generation sequencing of non-small cell lung cancer at a Quebec health care cancer centre

M Sorin, S Camilleri-Broët, E Pichette… - Cancer Treatment and …, 2023 - Elsevier
Background Lung cancer is the leading cause of cancer death in both men and women.
Quebec has the highest lung cancer mortality out of all provinces in Canada, believed to be …

Molecular biology and therapeutic perspectives for K-ras mutant non-small cell lung cancers

E Cekani, S Epistolio, G Dazio, M Cefalì, L Wannesson… - Cancers, 2022 - mdpi.com
Simple Summary Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene
are the most common alterations in non-small cell lung cancer (NSCLC); they are generally …

Assessing mutations in treatment response-related genes in Egyptian patients with non-small cell lung cancer

A Omar, A Bahnassy, R Gaafer, E El Desouky… - Asian Pacific Journal of …, 2022 - waocp.com
Background: Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral
oncogene homolog (K-RAS) are the most common driver genes in patients with non-small …

Sex-and Age-Associated Differences in Genomic Alterations among Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

EMO Kimbrough, JA Marin-Acevedo, LM Drusbosky… - Cancers, 2024 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer-related death. While sex and
age impact outcomes in non-small cell lung cancer (NSCLC), it is not clearly understood …

Analytical validation and clinical utilization of K-4CARE™: a comprehensive genomic profiling assay with personalized MRD detection

TP Nguyen Hoang, TA Nguyen, NHB Tran… - Frontiers in Molecular …, 2024 - frontiersin.org
Background: Biomarker testing has gradually become standard of care in precision
oncology to help physicians select optimal treatment for patients. Compared to single-gene …