Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Some familial platelet disorders are associated with predisposition to leukemia,
myelodysplastic syndrome (MDS) or dyserythropoietic anemia,. We identified a family with …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Platelets are essential for haemostasis, and thrombocytopenia (platelet counts< 150× 109/l)
is a major clinical problem encountered across a number of conditions, including immune …

Cancer-associated mortality is frequently caused by metastasis, however, our understanding
of this process remains incomplete and therapeutic options are limited. Metastasis is a …

Platelets are small, anucleate circulating cells that possess a dynamic repertoire of functions
spanning the hemostatic, inflammatory, and immune continuum. Once thought to be merely …

Ischemic stroke is among the leading causes of disability and death worldwide. In acute
ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary …

NBEAL2 encodes a multidomain scaffolding protein with a putative role in granule ontogeny
in human platelets. Mutations in NBEAL2 underlie gray platelet syndrome (GPS), a rare …

Genetic defects of platelets constitute rare diseases that include bleeding syndromes of
autosomal dominant, recessive or X‐linked inheritance. They affect platelet production …