In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Cardiovascular diseases are the most prevalent cause of morbidity and mortality among
patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Macrophages, found in circulating blood as well as integrated into several tissues and
organs throughout the body, represent an important first line of defense against disease and …

Individuals with type 2 diabetes mellitus have increased cardiovascular disease risk
compared with those without diabetes. Treatment of the residual risk, other than blood …

Machine learning is increasingly integrated into clinical practice, with applications ranging
from pre-clinical data processing, bedside diagnosis assistance, patient stratification …

The effects of e-cigarette (e-cig) aerosol inhalation by nonsmokers have not been examined
to date. The present study was designed to evaluate the acute response to aerosol …

The mechanisms that promote an inflammatory environment and accelerated
atherosclerosis in diabetes are poorly understood. We show that macrophages isolated from …