The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action
constitutes a “holy grail” for the field. Scientists have investigated several TH-dependent …

We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid
hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) …

Patients with mutations in the thyroid hormone (TH) cell transporter monocarboxylate
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …

Introduction Mutations and single nucleotide polymorphisms (SNPs) in the genes encoding
the network of proteins involved in thyroid hormone signaling (TH) may have implications for …

Abstract Introduction Levothyroxine (L-T4) monotherapy is the standard of care for the
treatment of hypothyroidism. A minority of the L-T4-treated patients remain symptomatic and …

The identification of critical factors that can worsen the mechanisms contributing to the
pathophysiology of Alzheimer disease is of paramount importance. Thyroid hormones (TH) …

Background: Normal brain development, mood, and cognitive functions depend on thyroid
hormone (TH) action. However, little is known about how TH mediates its actions in the …

Background The Thr92Ala-DIO2 polymorphism has been associated with clinical outcomes
in hospitalized patients with COVID-19 and neuropsychiatric diseases. This study examines …

Introduction: During the formation of neural circuits, the developing brain demonstrates
extraordinary plasticity, heavily influenced by hormones. These chemical messengers …

The Centenary of the American Thyroid Association (ATA) was celebrated in 2023, and I
was honored to present the “Year in Thyroidology: Basic Science” Lecture at the 92nd …