Interleukin (IL-) 2 and its receptor (IL-2R) constitute one of the most extensively studied
cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in …

Lymphocyte populations in the immune system are maintained by a well-organized balance
between cellular proliferation, cellular survival and programmed cell death (apoptosis (. One …

CD1d-restricted Vα14 invariant NKT (iNKT) cells play an important role in the regulation of
diverse immune responses. MicroRNA-mediated RNA interference is emerging as a crucial …

Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune
responses. During their development in the thymus, immature uncommitted double-positive …

CD8+ T cells are crucial for host defense against invading pathogens and malignancies.
However, relatively little is known about intracellular signaling events that control the genetic …

Abstract IL-2/IL-15Rβ-deficient mice display impaired development of NK cells, NKT cells,
and intraepithelial lymphocytes of the intestine and skin. To determine the role of survival …

The interleukin-2 receptor (IL-2R) is composed of one affinity-modulating subunit (IL-2Rα)
and two essential signaling subunits (IL-2Rβ and γc). Although most known signaling events …

Regulatory T cells (Tregs) play an important role in preventing both autoimmune and
inflammatory diseases. Many recent studies have focused on defining the signal …

Cytokine receptors activate signals that regulate the transcription factor E2F-1, which then
coordinates the expression of genes essential for DNA synthesis and cell cycle progression …

Immunological memory, a fundamental immune system mechanism, is instrumental in long-
term protection. Successful vaccines can elicit and sustain immunological memory against …