The immunology of rheumatoid arthritis
CM Weyand, JJ Goronzy - Nature immunology, 2021 - nature.com
The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
Single-cell transcriptomics in cancer: computational challenges and opportunities
Intratumor heterogeneity is a common characteristic across diverse cancer types and
presents challenges to current standards of treatment. Advancements in high-throughput …
presents challenges to current standards of treatment. Advancements in high-throughput …
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
Autism genes converge on asynchronous development of shared neuron classes
B Paulsen, S Velasco, AJ Kedaigle, M Pigoni… - Nature, 2022 - nature.com
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …
spanning a wide range of biological functions,,,,–. The alterations in the human brain …
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …
Early Alzheimer's disease pathology in human cortex involves transient cell states
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile
the transcriptomes of individual cells on a large scale. Early analyses of differential …
the transcriptomes of individual cells on a large scale. Early analyses of differential …
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …
CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets
High-dimensional mass and flow cytometry (HDCyto) experiments have become a method
of choice for high-throughput interrogation and characterization of cell populations. Here, we …
of choice for high-throughput interrogation and characterization of cell populations. Here, we …
IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation
Background Immunosuppressive and anti-cytokine treatment may have a protective effect for
patients with COVID-19. Understanding the immune cell states shared between COVID-19 …
patients with COVID-19. Understanding the immune cell states shared between COVID-19 …