Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

When stem cells divide, they can generate progeny with the same developmental potential
as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically …

The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is
dysregulated in various cancers, and its upregulation strongly correlates with an invasive …

Background Chromobox protein homolog 7 (CBX7), a member of the polycomb group (PcG)
family of proteins, is involved in the regulation of cell proliferation and cancer progression …

Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by
regulating chromatin structure and is indispensable for self-renewal of both normal and …

The polycomb group (PcG) proteins are epigenetic regulators of gene expression that
enhance cell survival. This regulation is achieved via action of two multiprotein PcG …

Identification of bona fide tumor suppressors is often challenging because of the large
number of genetic alterations present in most human cancers. To evaluate candidate genes …

Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and
their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic …

MicroRNAs (miRNAs) have emerged as important regulators of tumorigenesis. Several
miRNAs, which can function either as oncomiRs or tumor suppressive miRs are deregulated …

Deregulation of the polycomb group gene BMI-1 is implicated in the pathogenesis of many
human cancers. In this study, we have investigated if the Ewing sarcoma family of tumors …