Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …

Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …

Upregulation of special AT-rich sequence-binding protein-1 (SATB1) has been suggested to
promote tumor growth and metastasis. However, the factors governing its cellular levels …

DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain
of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both …

Ubiquitination, a post-translational modification that involves a covalent attachment of
ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end …

A‐lamins, encoded by the LMNA gene, are major structural components of the nuclear
lamina coordinating essential cellular processes. Mutations in the LMNA gene and/or …

Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most
malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 …

Development of effective strategies to manage the inevitable acquired resistance to
osimertinib, a third-generation EGFR inhibitor for the treatment of EGFR-mutant (EGFRm) …

Understanding molecular interactions and regulatory mechanisms in tumor initiation,
progression, and treatment response are key requirements towards advanced cancer …

The discovery of activating epidermal growth factor receptor (EGFR) mutations spurred the
use of EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib, as the first-line treatment of …