Alzheimer disease (AD) is the most frequent cause of dementia and up to now there is not
an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis …

Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) in monolayers
interact mechanically via cell–cell and cell–substrate adhesion. Spatiotemporal features of …

Abstract α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological
functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its …

Background The prevalence of heart failure is constantly increasing, and the prognosis of
patients remains poor. New treatment strategies to preserve cardiac function and limit …

Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is
an adaptive response to an increased cardiac workload that eventually leads to heart failure …

Protein kinase C (PKC) modulators hold therapeutic potential for various diseases, including
cancer, heart failure, and Alzheimer's disease. Targeting the C1 domain of PKC represents a …

Background The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and
leukocytes, where it regulates skin pigmentation and inflammatory responses. Recently …

Heart failure is a global health issue that can result from various factors, one of which is
myocardial infarction. The adult human heart has limited regenerative capacity to cover the …

Background α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological
functions by activating melanocortin receptors (MC-R). α-MSH is predominantly expressed …

The expression of PKCε, a member of the protein kinase C family, has been found to be
decreased in the frontal cortex of patients with Alzheimer's disease (AD). Bryostatin-1 is a …