Chemical Tools for the Study of DNA Repair

YW Jun, ET Kool - Accounts of chemical research, 2022 - ACS Publications
Conspectus DNA repair enzymes continuously provide surveillance throughout our cells,
protecting the enclosed DNA from the damage that is constantly arising from oxidation …

High-content Tailoring Strategy to Improve the Multifunctionality of Functional Nucleic Acids

K Chen, L Zhu, J Li, Y Zhang, Y Yu, X Wang… - Biosensors and …, 2024 - Elsevier
Functional nucleic acids (FNAs) have attracted increasing attention in recent years due to
their diverse physiological functions. The understanding of their conformational recognition …

A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications

RE Johnson, MT Murray, LJ Bycraft, SD Wetmore… - Chemical …, 2023 - pubs.rsc.org
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …

Multifaceted nucleic acid probing with a rationally upgraded molecular rotor

TK Kha, Q Shi, N Pandya, RY Zhu - Chemical Science, 2024 - pubs.rsc.org
Probing the sequence alterations, structures, interactions, and other important aspects of
nucleic acids serves as the cornerstone of understanding nucleic acid-mediated biology and …

Analyzing aptamer structure and interactions: in silico modelling and instrumental methods

DO Malysheva, MA Dymova, VA Richter - Biophysical Reviews, 2024 - Springer
Aptamers are short oligonucleotides that bind specifically to various ligands and are
characterized by their low immunogenicity, thermostability, and ease of labeling. Many …

Template‐Directed Incorporation of Functional Molecules into DNA

Z Kanlidere - ChemBioChem, 2023 - Wiley Online Library
We report a versatile method for the incorporation of functional molecules into
oligonucleotides carrying reactive groups by using a template‐directed postsynthetic …

Generation of abasic sites in DNA by singlet oxygen produced from a photocatalytic reaction

Y Yamano, K Onizuka, O Altan, M Sasaki… - 2024 - chemrxiv.org
Stress factors such as photoreaction and inflammation are known to damage nucleic acids
in various ways. Guanine, among the four canonical nucleobases, is particularly susceptible …

The Use of Primers Heavily Labeled with Fluorescein in Polymerase Chain Reaction

KG Ptitsyn, SA Khmeleva, LK Kurbatov… - … Research and Methods, 2023 - bmc-rm.org
The fluorescently-labeled DNA is widely used in various bioanalytical applications. For a
number of applications, a high level of labeling could be beneficial. One of the ways to …

Quantification and Sequencing of Oxidative DNA Damage

NJL Püllen - 2024 - research-collection.ethz.ch
DNA oxidation occurs frequently in our cells and is linked to both beneficial and detrimental
outcomes concerning human health. Exposure to chemicals or radiation can promote the …

[引用][C] [NEWS] 신진연구자소개_ 전용웅Yong Woong Jun

전용웅 - 화학세계, 2023 - dbpia.co.kr
전 용 웅 Page 1 2023. 06 CHEMWORLD 45 전용웅 교수는 DNA의 손상과 수리기작을 기반으로
생화학 연구를 수행해오고 있다. DNA 수리 단백질의 활성도를 측정할 수 있는 방법론을 개발하는 …